Compressed coated polypill with mucoadhesive core for cardiovascular disease – A review

A recent concept of polypill has evolved to include a number of key drugs in a single pill that can be used to prevent various diseases, especially cardiovascular diseases. Modeled economic analyses propose that such multidrug regimen would be cost effective in reducing the cardiovascular diseases in developing countries like India and Pakistan. Recently it has been recognized by Combination Pharmacotherapy and Public Health Research Working Group, the WHO and the World Heart Federation to use polypill on high-risk patient, with or without previous cardiovascular events. Various techniques have been proposed and developed to improve the coating and mucoadhesion techniques of polypill for greater adherence and bioavailability of drug at the site of action. The Compression Coating or Press Coating technique are undertaken to formulate polypill ensuring safety and efficacy. The present article signifies the importance of polypill in cardiovascular diseases and the coating techniques for the development of polypill.